| Autor: |
Bairova, T., Gommellya, M., Dolgich, V., Philippov, E., Kolesnikova, L. |
| Předmět: |
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| Zdroj: |
Russian Journal of Genetics; Feb2016, Vol. 52 Issue 2, p214-219, 6p |
| Abstrakt: |
A comparative estimation was conducted to assess the prevalence of genotypes and alleles of the R>Q(353) polymorphism of the coagulation factor FVII gene between a group of the Russian adolescents with essential arterial hypertension and a group of Russian adolescents without such health problems. The RR genotype was diagnosed in 55 adolescents (75.34%) of the control group and in 99 adolescents (84.61%) of the adolescents suffering from essential arterial hypertension (χ = 1.949, p = 0.163). The R allele frequency was, respectively, 85.62 and 91.88% (χ = 3.110, p = 0.078). The role of the FVII gene in the determination of the F7 plasma activity was defined in adolescents with essential arterial hypertension and holders of different alleles. Holders of the R allele had significantly higher activity of coagulation factor F7 (97.66 ± 15.48 against 83.37 ± 15.16, p = 0.002), factor F2 (107.45 ± 6.03 against 103.75 ± 6.81, p = 0.023), and antithrombin III (104.47 ± 15.54% against 95.87 ± 11.30%, p = 0.024). than holders of the Q allele. This relationship was not found in adolescents of the control group. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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