| Autor: |
Kilian, Krzysztof, Pękal, Anna, Juszczyk, Julia |
| Předmět: |
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| Zdroj: |
Nukleonika; Mar2016, Vol. 61 Issue 1, p29-33, 5p |
| Abstrakt: |
A method of 11C-methionine synthesis using 'bubbling' method is presented. 11C-methionine was synthesized via 11C methylation from L-cysteine thiolactone (2 mg) in a 300 μL solution of 2:1:1 (v/v) 1 M NaOH, ethanol, and water at ambient temperature (85°C, 5 min). The radiochemical purity of radiotracer was higher than 99% and enantiomeric purity (L-11C-methionine) was 91.6 ± 0.4%. The final product met the requirements of European Pharmacopoeia monograph. The proposed 11C-methionine synthesis is a reliable tool for routine manufacturing in clinical applications and animal studies. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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