| Autor: |
de Faria Garcia, Eliana, de Oliveira, Mariana Assíria, Candido, Luiza C. M., Coelho, Fernanda M., Vasconcelos Costa, Vivian, Queiroz-Junior, Celso Martins, Boff, Daiane, Almeida Amaral, Flávio, da Glória de Souza, Danielle, Martins Teixeira, Mauro, Castro Braga, Fernão |
| Předmět: |
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| Zdroj: |
Planta Medica; 2016, Vol. 82 Issue 5, p407-413, 7p |
| Abstrakt: |
The leaves of Echinodorus grandiflorus are traditionally used in Brazil to treat several inflammatory conditions, including arthritis. This study aimed to investigate the antiarthritis activity of the 70% ethanol extract of E. grandiflorus leaves and a standardized flavonoid-rich fraction in an antigen-induced arthritis model in mice. Previously immunized mice were treated per os with saline (control group), 70% ethanol extract (100- 1000 mg/kg), or a flavonoid-rich fraction (0.7- 7.2mg/kg) 40 minutes before and 3 and 6 hours after the challenge with antigen into the knee joint. The administration of the 70% ethanol extract and flavonoid-rich fraction to mice significantly reduced neutrophil recruitment to the joint cavity and in periarticular tissue. The levels of chemokine (C-X‑C motif) ligand 1, tumor necrosis factor-α, and interleukin-1β quantified by the enzyme-linked immunosorbent assay (ELISA) in the periarticular tissuewere also diminished in mice treated with the 70% ethanol extract and flavonoid-rich fraction, as well as mechanical hypernociception. Histological analysis confirmed that both the 70% ethanol extract and flavonoidrich fraction suppressed joint inflammation and inhibited cartilage and bone destruction when compared to the control group. Our results demonstrate, for the first time, that E. grandiflorus has anti-inflammatory activity in an experimental arthritis model and highlights the role of flavonoids in the observed response. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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