| Autor: |
Sun, Yang, Yang, Chao, Chen, Jieying, Song, Xin, Li, Zhen, Duan, Minlan, Li, Jianglin, Hu, Xiaoxiao, Wu, Kuangpei, Yan, Guobei, Yang, Cai, Liu, Jing, Tan, Weihong, Ye, Mao |
| Předmět: |
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| Zdroj: |
Journal of Cellular & Molecular Medicine; Apr2016, Vol. 20 Issue 4, p698-709, 12p |
| Abstrakt: |
WD-repeat protein 79 ( WDR79), a member of the WD-repeat protein family, acts as a scaffold protein, participating in telomerase assembly, Cajal body formation and DNA double-strand break repair. Here, we first report that WDR79 is frequently overexpressed in cell lines and tissues derived from non-small cell lung cancer ( NSCLC). Knockdown of WDR79 significantly inhibited the proliferation of NSCLC cells in vitro and in vivo by inducing cell cycle arrest and apoptosis. WD-repeat protein 79 -induced cell cycle arrest at the G0/G1 phase was associated with the expression of G0/G1-related cyclins and cyclin-dependent kinase complexes. We also provide evidence that WDR79 knockdown induces apoptosis via a mitochondrial pathway. Collectively, these results suggest that WDR79 is involved in the tumorigenesis of NSCLC and is a potential novel diagnostic marker and therapeutic target for NSCLC. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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