Peripherally Applied Synthetic Tetrapeptides HAEE and RADD Slow Down the Development of Cerebral β-Amyloidosis in AβPP/PS1 Transgenic Mice.

Autor:	Tsvetkov, Philipp O, Cheglakov, Ivan B, Ovsepyan, Armen A, Mediannikov, Oleg Y, Morozov, Alexander O, Telegin, Georgy B, Kozin, Sergey A
Předmět:	ANTIPSYCHOTIC agents BRAIN metabolism OLIGOPEPTIDES ALZHEIMER'S disease ANIMAL experimentation BIOLOGICAL models BRAIN INTRAVENOUS injections MEMBRANE proteins MICE GENETIC mutation PEPTIDES PROTEIN precursors THERAPEUTICS
Zdroj:	Journal of Alzheimer's Disease; 2015, Vol. 46 Issue 4, p849-853, 5p
Abstrakt:	Two tetrapeptides, HAEE and RADD, which are ionic-complementary to the primary zinc recognition site of amyloid-β (Aβ), have been reported to inhibit zinc-induced dimerization of the Aβ metal-binding domain and slow Aβ aggregation in vitro. In the present study, we investigate the impact of HAEE and RADD on the development of cerebral β-amyloidosis in a mouse model of Alzheimer's disease. We have found chronic intravenous administration of each peptide results in significant decrease of amyloid plaque burden in the treated mice. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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