| Autor: |
Abell, Thomas L., Cutsem, Eric Van, Abrahamsson, Hasse, Huizinga, Jan D., Konturek, J. W., Galmiche, Jean Paul, Voeller, Guy, Filez, Ludo, Everts, Bernt, Waterfall, William E., Domschke, W., Des Varannes, Stanislas Bruley, Familoni, Babajide O., Bourgeois, Lvan M., Janssens, Jozef, Tougas, Gervais |
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| Zdroj: |
Digestion; 2002, Vol. 66 Issue 4, p204-212, 9p, 5 Charts, 1 Graph |
| Abstrakt: |
Background: The treatment of gastroparesis remains unsatisfactory despite prokinetic and anti-emetic drugs. Gastric electrical stimulation has been proposed as a therapeutic option. We have assessed the effect of gastric electrical stimulation on symptoms, medical treatment, body weight and gastric emptying in patients with intractable symptomatic gastroparesis in a non-placebo-controlled study. Methods: In this multicenter study, 38 highly symptomatic patients with drug-refractory gastroparesis were enrolled. Patients first received temporary electrical stimulation using percutaneous electrodes. The 33 responders to temporary stimulation then underwent surgical implantation of a permanent stimulator. Severity of vomiting and nausea was assessed before and after stimulation. Patients were reassessed 3, 6, and 12 months after permanent implantation. Results: With stimulation, 35/38 patients (97%) experienced >80% reduction in vomiting and nausea. This effect persisted throughout the observation period (2.9–15.6 months, 341 patient-months). Gastric emptying did not initially change, but improved in most patients at 12 months. At 1 year, the average weight gain was 5.5% and 9/14 patients initially receiving enteral or parenteral nutrition were able to discontinue it. Conclusion: Electrical stimulation of the stomach has an immediate and potent anti-emetic effect. It offers a safe and effective alternative for patients with intractable symptomatic gastroparesis.Copyright © 2002 S. Karger AG, Basel [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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