| Autor: |
Denlinger, Rachel L., Smith, Tracy T., Murphy, Sharon E., Koopmeiners, Joseph S., Benowitz, Neal L., Hatsukami, Dorothy K., Pacek, Lauren R., Colino, Cirielle, Cwalina, Samantha N., Donny, Eric C. |
| Předmět: |
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| Zdroj: |
Tobacco Regulatory Science; Apr-Jun2016, Vol. 2 Issue 2, p186-203, 18p |
| Abstrakt: |
Research using very low nicotine content (VLNC) cigarettes has shown that participants underreport use of non-study cigarettes. Biomarkers of nicotine exposure could be used to verify compliance with VLNC cigarettes. This study aimed to characterize biomarkers of exposure when participants exclusively use VLNC cigarettes. Methods: Twenty-three participants stayed in a hotel that permitted smoking for 5 days and 4 nights. They were provided 2 packs of VLNC cigarettes each day (0.4 mg of nicotine/g of tobacco; Spectrum cigarettes) and did not have access to other tobacco products. Twenty-four-hour urine samples were collected to assess exposure to nicotine and anatabine. Results: After 4 days of exclusive use, the geometric means for urinary total cotinine, total nicotine equivalents (TNE), and anatabine were 1.13 nmol/ml (92% reduction), 3.17 nmol/ml (94% reduction) and 0.0031 nmol/ml (93% reduction) respectively. The population estimates of the 95th percentile of cotinine, TNE, and anatabine levels were 2.69, 6.41, and 0.0099 nmol/ml, respectively. Conclusions: Study participants exclusively smoking 0.4 mg/g Spectrum cigarettes are unlikely to have biomarker values above these levels. The data presented here will be valuable to researchers conducting research on use of VLNC cigarettes. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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