| Autor: |
Lücke, Daniel, Dalton, Toryn, Ley, Steven V., Wilson, Zoe E. |
| Předmět: |
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| Zdroj: |
Chemistry - A European Journal; Mar2016, Vol. 22 Issue 12, p4206-4217, 12p |
| Abstrakt: |
Flow chemistry has been successfully integrated into the synthesis of a series of cyclooligomeric depsipeptides of three different ring sizes including the natural products beauvericin ( 1 a), bassianolide ( 2 b) and enniatin C ( 1 b). A reliable flow chemistry protocol was established for the coupling and macrocyclisation to form challenging N-methylated amides. This flexible approach has allowed the rapid synthesis of both natural and unnatural depsipeptides in high yields, enabling further exploration of their promising biological activity. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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