| Autor: |
Schutte, Nienke M., Nederend, Ineke, Hudziak, James J., Bartels, Meike, de Geus, Eco J. C. |
| Předmět: |
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| Zdroj: |
Physiological Genomics; Mar2016, Vol. 48 Issue 3, p210-219, 10p |
| Abstrakt: |
Large individual differences exist in aerobic fitness in childhood and adolescence, but the relative contribution of genetic factors to this variation remains to be established. In a sample of adolescent twins and siblings (n = 479), heart rate (HR) and maximal oxygen uptake (VO2max) were recorded during the climax of a graded maximal exercise test. In addition, VO2max was predicted in two graded submaximal exercise tests on the cycle ergometer and the treadmill, using extrapolation of the HR/VO2 curve to the predicted HRmax. Heritability estimates for measured VO2max were 60% in ml/min and 55% for VO2max in ml·min-1·kg-1. Phenotypic correlations between measured VO2max and predicted VO2max from either submaximal treadmill or cycle ergometer tests were modest (0.57 < r < 0.70), in part because of the poor agreement between predicted and actual HRmax. The majority of this correlation was explained by genetic factors; therefore, the submaximal exercise tests still led to very comparable estimates of heritability of VO2max. To arrive at a robust estimate for the heritability of VO2max in children to young adults, a sample size weighted meta-analysis was performed on all extant twin and sibling studies in this age range. Eight studies, including the current study, were meta-analyzed and resulted in a weighted heritability estimate of 59% (ml/min) and 72% (ml·min-1·kg-1) for VO2max. Taken together, the twin-sibling study and meta-analyses showed that from childhood to early adulthood genetic factors determine more than half of the individual differences in VO2max. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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