EMMPRIN expression is involved in the development of interstitial fibrosis and tubular atrophy in human kidney allografts.

Autor: Kemmner, Stephan, Schulte, Christian, Hann von Weyhern, Claus, Schmidt, Roland, Baumann, Marcus, Heemann, Uwe, Renders, Lutz, Schmaderer, Christoph
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Zdroj: Clinical Transplantation; Mar2016, Vol. 30 Issue 3, p218-225, 8p
Abstrakt: Background Matrix metalloproteinases ( MMP) are involved in the development of interstitial fibrosis and tubular atrophy ( IF/ TA) in renal disease. The synthesis of MMP is activated by the extracellular matrix metalloproteinases inducer protein ( EMMPRIN). To analyze the role of EMMPRIN in IF/ TA, we retrospectively detected EMMPRIN expression in specimens of human renal allografts with various levels of IF/ TA. Methods Immunohistochemistry was performed to detect EMMPRIN expression. In a retrospective analysis, a total cohort of 50 specimens were divided according to BANFF-classification into four subgroups (0-3): no, mild (≤25%), moderate (26-50%), or severe (>50%) IF/ TA. Among other parameters, renal function was analyzed and compared to EMMPRIN expression. Results In 24 of 38 biopsies, we detected positive EMMPRIN staining. All nephrectomy (n = 12) samples were negative for EMMPRIN. Positive staining in the biopsy samples was detectable on the basolateral side of tubular epithelial cells. EMMPRIN staining was negatively correlated with IF/ TA (p < 0.001). We found significant differences between the mean EMMPRIN expression in IF/ TA groups 0 and 3 (p = 0.021) and groups 1 and 3 (p = 0.004). Furthermore, we found significant correlations between EMMPRIN staining and renal function. Conclusion Our data suggest that EMMPRIN is involved in the pathophysiology of IF/ TA. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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