| Autor: |
Ta, Chieu Anh Kim, Guerrero ‐ Analco, J. Antonio, Roberts, Elizabeth, Liu, Rui, Mogg, Christopher D., Saleem, Ammar, Otárola ‐ Rojas, Marco, Poveda, Luis, Sanchez ‐ Vindas, Pablo, Cal, Victor, Caal, Federico, Subramaniam, Rajagopal, Smith, Myron L., Arnason, John T. |
| Zdroj: |
Phytotherapy Research; Mar2016, Vol. 30 Issue 3, p439-446, 8p |
| Abstrakt: |
Bioassay-guided fractionation of the crude extract (80% EtOH) of the leaves of Cestrum schlechtendahlii, a plant used by Q'eqchi' Maya healers for treatment of athlete's foot, resulted in the isolation and identification of two spirostanol saponins (1 and 2). Structure elucidation by MS, 1D-NMR, and 2D-NMR spectroscopic methods identified them to be the known saponin (25R)-1β,2α-dihydroxy-5α-spirostan-3-β-yl-O-α-L-rhamnopyranosyl-(1 → 2)-β-D-galactopyranoside (1) and new saponin (25R)-1β,2α-dihydroxy-5α-spirostan-3-β-yl-O-β-D-galactopyranoside (2). While 2 showed little or no antifungal activity at the highest concentration tested, 1 inhibited growth of Saccharomyces cerevisiae (minimum inhibitory concentration (MIC) of 15-25 μM), Candida albicans, Cryptococcus neoformans, and Fusarium graminearum (MIC of 132-198 μM). [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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