| Autor: |
Ogino, Yoshio, Sakamoto, Yoshikazu, Kinouchi, Takashi, Shimizu, Naokata |
| Předmět: |
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| Zdroj: |
Pharmacology; Jul2000, Vol. 61 Issue 1, p11-13, 3p, 1 Graph |
| Abstrakt: |
Kinetic interaction between thrombin receptor and G proteins was investigated in human epithelial neuroblastoma cell line, SH-EP. In these cells, both α-thrombin and SFLLRNP (one-letter amino-acid code) stimulated GTPase activity and enhanced cholera toxin-catalyzed ADP-ribosylation of G[sub i2] in a concentration-dependent manner. Basal GTPase activity was attenuated by pertussis toxin treatment by 35%, however, agonist stimulation was preserved significantly. These results together indicated that thrombin receptor simultaneously activates G[sub i2] and PTX-insensitive G protein(s).Copyright © 2000 S. Karger AG, Basel [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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