| Autor: |
Fucharoen, Supan, Fucharoen, Goonnapa, Sanchaisuriya, Kanokwan, Surapot, Satja |
| Předmět: |
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| Zdroj: |
Acta Haematologica; 2002, Vol. 108 Issue 3, p157-161, 5p |
| Abstrakt: |
We report the molecular and hematological characterizations of thalassemia caused by interactions of the hereditary persistence of fetal hemoglobin (HPFH)-6 with β-thalassemia in 2 Thai patients and the HPFH-6 with Hb E in another Thai patient. Marked hypochromic microcytosis, characteristics of thalassemia intermedia, were obvious in the former 2 cases but the latter had much milder clinical phenotype with normal Hb and a slightly reduced mean corpuscular volume (MCV) value. Hb analysis revealed no Hb A but Hb A[sub 2] F patterns in the compound HPFH-6/β-thalassemia patients and the EF pattern in the HPFH-6/Hb E patient. The [sup G] γ-globin chain predominated in all cases. Globin gene analyses demonstrated that all patients carried the 101-kb HPFH-6 deletion in trans to the β-thalassemia genes with the IVS1#5 G–C mutation and the G insertion between codons 8/9 and the β[sup E] -gene, respectively. Hematologic data of the patients were compared to those of the HPFH-6 heterozygotes found in their family members and different genotype-phenotype interactions of this HPFH determinant in these Thai patients are illustrated.Copyright © 2002 S. Karger AG, Basel [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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