| Autor: |
Rigotti, Gino, Charles-de-Sá, Luiz, Gontijo-de-Amorim, Natale Ferreira, Takiya, ChristinaMaeda, Amable, Paola Romina, Borojevic, Radovan, Benati, Donatella, Bernardi, Paolo, Sbarbati, Andrea, Takiya, Christina Maeda |
| Zdroj: |
Aesthetic Surgery Journal; 03/01/2016, Vol. 36 Issue 3, p261-270, 10p |
| Abstrakt: |
Background: In a previous study, the authors demonstrated that treatment with expanded adipose-derived stem cells or stromal vascular fraction (SVF)-enriched fat modify the pattern of the dermis in human beings, representing a skin rejuvenation effect. Considering that expanded stem cells require a cell factor, the authors wanted to assess similar results by replacing them with platelet-rich plasma (PRP), which is easier to obtain and for which an empirical regenerative effect has been already described.Objectives: To determine if PRP injection could replace the cutaneous regenerative effect of adipose-derived stem cells.Methods: This study was performed in 13 patients who were candidates for facelift. The patients underwent sampling of fat by liposuction from the abdomen and submitted to one of three protocols: injection of SVF-enriched fat or expanded adipose-derived stem cells or fat plus PRP in the preauricular areas. Fragments of skin were removed before and 3 months after treatment and analyzed by optical and electron microscopy.Results: The use of fat plus PRP led to the presence of more pronounced inflammatory infiltrates and a greater vascular reactivity, increasing in vascular permeability and a certain reactivity of the nervous component. The addition of PRP did not improve the regenerative effect.Conclusion: The use of PRP did not have significant advantages in skin rejuvenation over the use of expanded adipose-derived stem cells or SVF-enriched fat. The effect of increased vascular reactivity may be useful in pathological situations in which an intense angiogenesis is desirable, such as tissular ischemia. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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