| Autor: |
Rahmani, Asghar, Moradkhani, Atefeh, Hafezi Ahmadi, Mohammad Reza, Jafari Heirdarlo, Ali, Abangah, Ghobad, Asadollahi, Khairollah, Sayehmiri, Kourosh |
| Předmět: |
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| Zdroj: |
Scandinavian Journal of Gastroenterology; May2016, Vol. 51 Issue 5, p531-537, 7p |
| Abstrakt: |
BackgroundGastritis is an important premalignant lesion and recent studies suggested a production of inflammatory cytokine-like C-reactive protein during gastritis. This study aimed to determine any relationship between high sensitive C-reactive protein (hs-CRP) and inflammation activity among patients with gastritis.MethodsDemographic and clinical variables of participants were collected by a validated questionnaire. Using histology of the gastric mucosa,Helicobacter pyloristatus was investigated and serum concentrations of hs-CRP were measured among dyspeptic patients. Correlation between hs-CRP serum levels and inflammation activities was evaluated by logistic regression analysis. The relation between active inflammation and other variables was evaluated by logic link function model.ResultsTotally 239 patients (56.6% female) were analysed. The prevalence of mild, moderate and severe inflammation activities was 66.5%, 23.8% and 9.6% respectively. Mean ± SD of hs-CRP among men and women were 2.85 ± 2.84 mg/dl and 2.80 ± 4.80 mg/dl (p = 0.047) respectively. Mean ± SD of hs-CRP among patients withH. pyloriinfection, gland atrophy, metaplasia and dysplasia were 2.83 ± 3.80 mg/dl, 3.52 ± 5.1 mg/dl, 2.22 ± 2.3 mg/dl and 5.3 ± 5.04 mg/dl respectively. Relationship between hs-CRP and inflammation activities (p < 0.01) was significant. A significant relationship between dysplasia and hs-CRP (p < 0.04) was revealed. A significant relationship between age and hs-CRP was detected (p < 0.05).ConclusionAlthough serum hs-CRP is not a specific biomarker for gastritis, elevated hs-CRP levels may be considered as a predictive marker of changes in gastric mucosa and a promising therapeutic target for patients with gastritis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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