| Autor: |
Yi-Wen Liu, Lu-Ming Yu, Po-Jui Wu |
| Předmět: |
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| Zdroj: |
AIP Conference Proceedings; 2016, Vol. 1703, p090028-1-090028-5, 5p |
| Abstrakt: |
The medial olivocochlear reflex (MOCR) is known to affect cochlear signal processing via the electromechanical changes it induces in outer hair cells (OHCs). Experiments showed that electrically stimulating the MOC efferents (i.e., openloop stimulation) suppresses cochlear responses to acoustic noise while enhancing the response to tone bursts if the signalto- noise ratio is sufficiently high [5]. However, such experiments did not reveal precisely how MOCR affects cochlear signal processing in a close loop. Presently we have built an integrated computer model for the MOCR pathway; the constituting sub-models include a model for cochlear mechanics with electromotile OHCs [11], a neurotransmitter release model for the synapse between inner hair cells (IHCs) and spiral ganglion cells [16], an electrical model for the T-multipolar (TM) cells in the cochlear nucleus [6], a relay from TM cells to the MOC interneurons, and a convolution kernel describing the change of OHC potassium conductance triggered by the MOC inhibitory post synaptic potentials. Thus, close-loop responses of the entire system can be simulated for arbitrary acoustic stimuli. Both open-loop and close-loop simulations demonstrate a decrease in the auditory nerve fiber (ANF) response to noise but an increase in the response to high-level tone bursts. The present integrated computer model can potentially be used for testing hypotheses regarding the physiological mechanisms for MOC anti-masking effects. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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