| Autor: |
Kasprowicz, Victoria O., Tan-Yun Cheng, Ndung'u, Thumbi, Sunpath, Henry, Branch Moody, D., Kasmar, Anne G., Cheng, Tan-Yun, Moody, D Branch |
| Předmět: |
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| Zdroj: |
Journal of Infectious Diseases; 2/15/2016, Vol. 213 Issue 4, p628-633, 6p |
| Abstrakt: |
Single-cell analysis captures the heterogeneity of T-cell populations that target defined antigens. Human immunodeficiency virus (HIV) infection results in defects of antimycobacterial immunity, which remain poorly defined. We therefore recruited a small number of subjects, including those with latent and active M. tuberculosis infection, with or without concomitant HIV infection, and tracked the mycobacterial glycolipid-reactive T-cell repertoire by using CD1b tetramers. Glycolipid-reactive T cells expressed memory markers and the HIV coreceptors CD4 and CCR5; they were not detected in subjects with HIV-associated active M. tuberculosis infection. HIV infection may affect T cells that recognize mycobacterial glycolipids and influence immunity. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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