| Autor: |
Tanihara, Hidenobu, Inoue, Toshihiro, Yamamoto, Tetsuya, Kuwayama, Yasuaki, Abe, Haruki, Fukushima, Atsuki, Suganami, Hideki, Araie, Makoto, Uchino, Miki, Iwasaki, Miki, Ono, Koichi, Sekiyama, Eiichi, Takahashi, Yoshinori, Fujie, Keiko, Shin, Hideyo, Kaneko, Taku, Shiba, Hiroharu, Ijuin, Nobuo, Tani, Emiko, Manabe, Yoichi |
| Předmět: |
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| Zdroj: |
Acta Ophthalmologica (1755375X); Feb2016, Vol. 94 Issue 1, pe26-e34, 9p |
| Abstrakt: |
Purpose To investigate the intra-ocular pressure ( IOP)-lowering effects and safety of 0.4% ripasudil (K-115), a Rho kinase inhibitor, twice daily for 52 weeks, in patients with open-angle glaucoma or ocular hypertension ( OHT). Methods In this multicentre, prospective, open-label study, 388 patients with primary open-angle glaucoma, OHT or exfoliation glaucoma were enrolled and 354 of them were subdivided into four cohorts (monotherapy, 173; additive therapy to prostaglandin analogs, 62; β-blockers, 60; or fixed combination drugs, 59). The IOP reduction at trough and peak from baseline and adverse events was investigated. Results Ripasudil showed IOP-lowering effects over 52 weeks in all the analyses of monotherapy, additive therapy and both subgroups (baseline IOP ≥21 mmHg and <21 mmHg) of monotherapy. The mean IOP reductions at trough and peak at week 52 were −2.6 and −3.7 mmHg for monotherapy, and −1.4 and −2.4, −2.2 and −3.0, and −1.7 and −1.7 mmHg, respectively, for additive therapy described above. The most frequently observed adverse events were conjunctival hyperaemia ( n = 264, 74.6%), blepharitis ( n = 73, 20.6%) and allergic conjunctivitis ( n = 61, 17.2%). Most of the conjunctival hyperaemia findings were mild (97.0%), transient and resolved spontaneously (78.0%). Although 51 patients discontinued from the study due to blepharitis and/or allergic conjunctivitis (blepharitis, 28; allergic conjunctivitis, 17; both, 6), all the events resolved with or without treatment after the discontinuation of ripasudil administration. Conclusion Fifty-two week administration of 0.4% ripasudil revealed IOP-lowering effects and an acceptable safety profile when administered as monotherapy or as additive therapy, in patients with open-angle glaucoma or OHT. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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