| Autor: |
Perez, Omar D., Mitchell, Dennis, Jager, Gina C., South, Sharon, Murriel, Chris, McBride, Jacqueline, Herzenberg, Lee A., Kinoshita, Shigemi, Nolan, Garry P. |
| Předmět: |
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| Zdroj: |
Nature Immunology; Nov2003, Vol. 4 Issue 11, p1083, 10p |
| Abstrakt: |
Leukocyte functional antigen 1 (LFA-1), with intercellular adhesion molecule ligands, mediates T cell adhesion, but the signaling pathways and functional effects imparted by LFA-1 are unclear. Here, intracellular phosphoprotein staining with 13-dimensional flow cytometry showed that LFA-1 activation induced phosphorylation of the ß2 integrin chain and release of Jun-activating binding protein 1 (JAB-1), and mediated signaling of kinase Erk1/2 through cytohesin-1. Dominant negatives of both JAB-1 and cytohesin-1 inhibited interleukin 2 production and impaired T helper type 1 differentiation. LFA-1 stimulation lowered the threshold of T cell activation. Thus, LFA-1 signaling contributes to T cell activation and effects T cell differentiation. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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