| Autor: |
Jugulete, Gh., Stancescu, A., Marin, L., Popescu, C., Merişescu, M., Schiopu, S., Osman, E., Luminos, M. |
| Předmět: |
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| Zdroj: |
Jurnalul Pediatrului; 2015 Supp 3, Vol. 18, p136-139, 4p |
| Abstrakt: |
Introduction: The pediatric cases of Clostridium Difficile infection (CDI), based on the host immune status, can present under a broad spectrum of clinical forms, from asymptomatic portage of the germ up to severe, life-threatening cases of pseudomembranous colitis. Objective: In this work we aimed to analyze the clinical forms and treatment of Clostridium Difficile colitis in children. Material and method: We conducted a clinic-based retrospective study in witch we analyzed the cases of confirmed CDI in infants and children that were treated and monitored at The National Institute for Infectious Diseases "Prof. Dr. Matei Bals", Bucharest during the period 2010 - 2014. For the selected cases the clinical and demographic patient features followed were: age, sex, immune status, severity of the disease and the treatment regimen. The etiological diagnosis was made by culturing the stool samples and by PCR testing for Toxigenic Clostridium Difficile strains. Results. During the study period we registered 20 cases of CDI in infants and children. On subsets, 25% of the cases were immunosuppressed. Based on the demographic features we observed female predominance and a pick of incidence in the 4-8 years subgroup. All the diagnosed patients were treated according to the international CDI treatment protocol. We registered a 15% recurrences rate, with one or two relapsing episodes. One tenth of our cases pretended more than 3 CDI relapsing episodes and consequently received fecal microbiota transplantation with the transplanted material being donated by a healthy family member, with subsequent full recovery. The cases that underwent the stool transplant protocol did not registered relapsing episodes. No fatal cases were registered. Conclusions: The CID in infants and children, especially in imunocompromised hosts, can present under sever clinical forms. In the case of multiple relapsing episodes the fecal microbiota transplantation procedure can be a successful treatment option. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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