| Autor: |
Jena, Amitabh, Patnayak, Rashmi, Suresh, Vaikkakara, Sachan, Alok, Vijaylaxmi, Bodagala, Manilal, Banoth |
| Předmět: |
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| Zdroj: |
Clinical Cancer Investigation Journal; Jan/Feb2016, Vol. 5 Issue 1, p52-55, 4p |
| Abstrakt: |
Multiple endocrine neoplasia-2A (MEN-2A) is a rare syndrome. MEN-2 is characterized by medullary thyroid carcinoma (MTC), pheochromocytoma, and hyperparathyroidism. MTC is the most consistent feature in all subtypes of MEN-2. In MEN-2A, approximately 70-95% of individuals develop MTC, 50% develop pheochromocytoma, and 15-30% develop hyperparathyroidism. Identification of a germline REarranged in transfection mutation or the identification of the clinical features of MEN-2A in other first-degree relatives is required to make the diagnosis, in those patients with only one or two clinical features. We present the case of a family with MEN-2A syndrome. Here, the patient was first operated for MTC and following further investigation was detected to have pheochromocytoma. In her family history, she had a daughter who was earlier operated for MTC. After 5 years of follow-up, she is doing well. This is an additional case of MEN-2A. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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