| Autor: |
Gliga, Camelia, Paşcanu, Ionela, Gliga, Marius, Gliga, Maximilian |
| Předmět: |
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| Zdroj: |
Jurnalul Pediatrului; Jul-Dec2015, Vol. 18 Issue 71/72, p64-67, 4p |
| Abstrakt: |
The term of osteogenesis imperfecta (OI) includes a heterogeneous group of genetic disorders of connective tissue and has as the main form of expression recurrent fractures, skeletal fragility and deformity. OI is one of the most common skeletal dysplasias. The disease has an etiology related directly or indirectly to type I collagen, the most important protein of the bone extracellular matrix. The diagnosis of OI is based on history and clinical examination associated with genetic analyses, imaging and laboratory investigations. OI is a disorder which has many clinical manifestations, some of these are present only in certain types of the disease, some characteristics being agedependent. There is no cure for OI. Treatment is aimed at increasing bone strenght to prevent fracture, the surgical correction of deformity, minimizing pain and maximizing mobility and independent function. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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