| Autor: |
Tittarelli, E., Barrero, P. R., Mistchenko, A. S., Valinotto, L. E. |
| Předmět: |
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| Zdroj: |
Tropical Medicine & International Health; Jan2016, Vol. 21 Issue 1, p28-32, 5p, 1 Chart, 1 Graph |
| Abstrakt: |
OBJECTIVES To evaluate the occurrence of secondary dengue virus (DENV) infections during the 2009 outbreak in a non-endemic area. Viral loads were evaluated in serum from acute-phase patients, comparing primary and secondary infection. METHODS Serum samples from patients with clinical diagnosis of suspected dengue were referred to the Virology Laboratory at 'Ricardo Gutiérrez' Children's Hospital. Dengue-positive samples were classified as primary or secondary DENV infections through serological methods (anti-DENV IgM and IgG). Viral loads were measured by quantitative real-time PCR (qRT-PCR) in samples obtained in the first 5 days of infection. Statistical analyses were performed to evaluate factors that might correlate with differences in the viral load of primary or secondary infection. RESULTS A total of 229 DENV cases were confirmed; among them, 22.7% were secondary infections. No significant differences were found between the viral load of primary and secondary infections. CONCLUSION We detected a high percentage of secondary DENV infections in a non-endemic area; this finding might correspond to socio-demographic characteristics of the group under study or indicate a previous cryptic DENV circulation causing inapparent infections. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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