| Autor: |
Pandey, Usha, Gamre, Naresh, Kumar, Yogendra, Shetty, Priyalatha, Sarma, Haladhar, Dash, Ashutosh |
| Předmět: |
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| Zdroj: |
Journal of Radioanalytical & Nuclear Chemistry; Jan2016, Vol. 307 Issue 1, p187-194, 8p, 1 Diagram, 4 Charts, 2 Graphs |
| Abstrakt: |
This paper explores the utility of para isothiocyanato benzyl 3,6,9,15-tetraazabicyclo [9.3.1]pentadeca-1(15),11,13-triene-3,6,9-triacetic acid (PCTA-NCS) as a bifunctional chelating agent for Lu in comparison to para isothiocyanato benzyl 1,4,7,10-tetra aza cyclododecane tetraacetic acid (DOTA-NCS). The Lu-PCTA-NCS complex could be obtained in high radiolabeling yields at ambient temperature and exhibited excellent stability in vitro. Influence of trace metal ions on the radiolabeling yields was also evaluated. Biodistribution studies revealed no significant retention of Lu-PCTA-NCS in any vital organ at 24 h p.i. It could be concluded from our study that PCTA-NCS could be a potential BFCA for design of Lu radiopharmaceuticals. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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