| Autor: |
Chotchaeva, Z., Shcheglova, E., Boeva, O., Hait, G., Magazinyuk, T., Rogova, S., Baikulova, M., Laipanova, A. |
| Zdroj: |
Advances in Gerontology; Oct2015, Vol. 5 Issue 4, p225-230, 6p |
| Abstrakt: |
A study on the serum concentrations of matrix metalloproteinase 9 ( MMP9) and tissue inhibitor of matrix metalloproteinases type 1 ( TIMP1) was carried out in 108 patients over the age of 65 with calcinosis and/or calcific aortic valve (AV) stenosis to uncover the molecular and genetic markers predisposing one to the development of senile aortic stenosis. Typing of the polymorphic loci A8202G of MMP9 gene ( rs1169732) and C536T of TIMP1 gene ( rs11551797) was also performed. Forty-six patients without AV calcinosis symptoms were examined as a control group. It was found that senile aortic stenosis is accompanied by a reliable increase in the serum concentration of TIMP1 (257.5 (151.5-325.9) pg/mL against 129.7 (86.2-229) pg/mL, p < 0.05), while TIMP1 level higher than 258.1 pg/mL in elderly persons over the age of 65 can be considered a high-precision marker of the discussed pathology. Polymorphism of the MMP9 ( A8208 G) and TIMP1 ( C536 T) genes is not associated with calcific aortic stenosis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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