| Autor: |
Cresswell, Alexander J., Eey, Stanley T.‐C., Denmark, Scott E. |
| Předmět: |
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| Zdroj: |
Angewandte Chemie International Edition; 12/21/2015, Vol. 54 Issue 52, p15642-15682, 41p |
| Abstrakt: |
Although recent years have witnessed significant advances in the development of catalytic, enantioselective halofunctionalizations of alkenes, the related dihalogenation of olefins to afford enantioenriched vicinal dihalide products remains comparatively underdeveloped. However, the growing number of complex natural products bearing halogen atoms at stereogenic centers has underscored this critical gap in the synthetic chemists arsenal. This Review highlights the selectivity challenges inherent in the design of enantioselective dihalogenation processes, and formulates a mechanism-based classification of alkene dihalogenations, including those that may circumvent the "classical" haliranium (or alkene-dihalogen µ-complex) intermediates. A variety of metal and main group halide reagents that have been used for the dichlorination or dibromination of alkenes are discussed, and the proposed mechanisms of these transformations are critically evaluated. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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