Anti-obesity and lipid lowering effects of Cymodocea nodosa sulphated polysaccharide on high cholesterol-fed-rats.

Autor: Ben Abdallah Kolsi, Rihab, Ben Gara, Amel, Chaaben, Rim, El Feki, Abdelfattah, Paolo Patti, Francesco, El Feki, Lotfi, Belghith, Karima
Předmět:
Zdroj: Archives of Physiology & Biochemistry; Dec2015, Vol. 121 Issue 5, p210-217, 8p
Abstrakt: This study aims to evaluate for the first time the effects ofCymodocea nodosasulphated polysaccharide (CNSP) on lipase activityin vitroandin vivoto high fat diet (HFD)-rats on body weight, lipid profile and liver-kidney functions. The administration of CNSP decreases the body weight and inhibits lipase activity of obese rats in serum and intestine as compared with untreated HDF-rats. This decrease in lipase activity leads to lipid regulation shown by the decrease of total cholesterol (T-Ch), triglycerides (TG) and low density lipoprotein cholesterol (LDL-C) and an increase in high density lipoprotein cholesterol (HDL-C) levels in HFD-rats. Additionally, CNSP administration to HFD-rats induces anti-oxidant activity observed by the increase of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) activities and the decrease in Thiobarbituric acid reactive substances (TBARS) levels and protects liver-kidney functions proven by a decrease in the levels of toxicity parameters in blood. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje