Site-specific conjugation of drug-like fragments to an antimiR scaffold as a strategy to target miRNAs inside RISC.

Autor:	BrunschweigerCurrent address: Faculty of Chemistry and Chemical Biology TU Dortmund University Otto-Hahn-Str.6 44227 Dortmund Germany., A., Gebert, L. F. R., Lucic, M., Pradère, U., Jahns, H., Berk, C., Hunziker, J., Hall, J.
Předmět:	MICRORNA POLYMERASE chain reaction NUCLEIC acids STRUCTURE-activity relationships RING formation (Chemistry) RNA interference
Zdroj:	Chemical Communications; 1/4/2016, Vol. 52 Issue 1, p156-159, 4p
Abstrakt:	We synthesized a miR-122 antimiR library in which drug-like fragments were site-specifically introduced to short 2′-O-methyl-RNAs. At some sites selected fragments elevated cellular antimiR activity to that of an unmodified 23mer antimiR, whereas at others the same fragments abolished activity. The potency of the antimiRs correlated with uptake into miRISC. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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