| Autor: |
Weir, R.E., Fine, P.E.M., Nazareth, B., Floyd, S., Black, G.F., King, E., Stanley, C., Bliss, L., Branson, K., Dockrell, H.M. |
| Předmět: |
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| Zdroj: |
Clinical & Experimental Immunology; Nov2003, Vol. 134 Issue 2, p285, 10p |
| Abstrakt: |
The immune responses of schoolchildren in southeast England to Mycobacterium tuberculosis and other species of mycobacteria were studied prior to vaccination with bacille Calmette-Guérin (BCG). Data are presented for tuberculin (Heaf) skin test and interferon- γ (IFN- γ) responses to M. tuberculosis purified protein derivative (PPD), and IFN- γ responses to PPDs from eight other environmental mycobacteria, measured in 424 schoolchildren (13–15 years of age). Responses to M. tuberculosis PPD were detected in 27% of schoolchildren by in vitro IFN- γ response and in 20% by the Heaf test. IFN- γ responses were more prevalent to PPDs from species of mycobacteria other than M. tuberculosis, predominantly those of the MAIS complex and M. marinum (45–60% responders). Heaf test and IFN- γ responses were associated ( P < 0·001) for M. tuberculosis, MAIS and M. marinum. These findings have implications for appropriate implementation of vaccination against tuberculosis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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