| Autor: |
Bella, Ramona, Dolci, Maria, Ferraresso, Mariano, Ticozzi, Rosalia, Ghio, Luciana, Rizzo, Jacopo, Signorini, Lucia, Villani, Sonia, Elia, Francesca, Ferrante, Pasquale, Delbue, Serena |
| Zdroj: |
Future Virology; Dec2015, Vol. 10 Issue 12, p1275-1284, 10p |
| Abstrakt: |
Aims: Human herpesvirus-6 (HHV-6) and polyomaviruses (HPyV) establish latency and reactivate in immunocompromised hosts. The prevalence of their infections was investigated in pediatric and young adult kidney transplant recipients. Materials & methods: Blood was obtained from 83 patients. Quantitative real-time polymerase chain reactions were conducted to quantify HHV-6 and HPyV loads; nested PCR and reverse transcriptase-PCR assays were conducted to differentiate HHV-6A from 6B and to evaluate the presence of transcripts. Results: HHV-6 and HPyV DNAemia were detected in 19.3 and 18.1% patients, respectively. No association between HHV-6 and HPyV DNA presence, age of patients and time from transplant was observed. Conclusion: HHV-6 infection in immunosuppression setting was as common as those of HPyVs that are commonly recognized as opportunistic agents. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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