Freezing the Butterfly Motion of Carbamazepine Derivatives.

Autor: Yuki Kanase, Mai Kuniyoshi, Hidetsugu Tabata, Yuka Takahashi, Susumu Kayama, Shintaro Wakamatsu, Tetsuta Oshitari, Hideaki Natsugari, Hideyo Takahashi
Předmět:
Zdroj: Synthesis; 2015, Vol. 47 Issue 24, p3907-3913, 7p
Abstrakt: Atropisomeric properties were found in carbamazepine derivatives. The atropisomers of N-acyl and N-thiocarbamoyl derivatives of carbamazepine were isolated, with high stereochemical stability. It has been elucidated that the rotation about the N-C1' axis around the outer amide N-(C=O) does not coordinate with the rotation of the butterfly- like motion. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index