Visceral basidiobolomycosis: An overlooked infection in immunocompetent children.

Autor: Mandhan, Parkash, Hassan, Kamal Osman, Samaan, Sandra Moustafa, Ali, Mansour J.
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Zdroj: African Journal of Paediatric Surgery; Jul-Sep2015, Vol. 12 Issue 3, p193-196, 4p, 2 Color Photographs, 1 Black and White Photograph
Abstrakt: Visceral basidiobolomycosis is an unusual fungal infection of viscera caused by saprophyte Basidiobolus ranarum. It is very rare in healthy children and poses a diagnostic challenge due to the non-specific clinical presentation and the absence of predisposing factors. We report a case of gastrointestinal basidiobolomycosis in a 4-year-old healthy girl who presented with a short history of abdominal pain, bleeding per rectum, fever, and weight loss. The diagnosis was based on high eosinophilic count, classical histopathology findings of fungal hyphae (the Splendore-Hoeppli phenomenon), and positive fungal culture from a tissue biopsy. Fungal infection was successfully eradicated with a combined approach of surgical resection of the infected tissue and a well-monitored course of antifungal therapy. The atypical clinical presentation, diagnostic techniques, and the role of surgery in the management of a rare and lethal fungal disease in an immunocompetent child are discussed. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index