Preparation of porous PLA/DBM composite biomaterials and experimental research of repair rabbit radius segmental bone defect.

Autor:	Zhang, Yumin, Wang, Jianru, Wang, Jue, Niu, Xiaojun, Liu, Jianchun, Gao, Lan, Zhai, Xiaoyan, Chu, Kaibo
Předmět:	ANIMAL experimentation BONE substitutes BONES BONE fractures HISTOLOGICAL techniques LACTIC acid MATERIALS testing PHYSICS POLYMERS RABBITS RADIUS bone injuries TREATMENT effectiveness FRACTURE healing THERAPEUTICS
Zdroj:	Cell & Tissue Banking; Dec2015, Vol. 16 Issue 4, p615-622, 8p
Abstrakt:	Bone substitutes are used in wide range of orthopaedic application. An ideal bone substitute should exhibit superior osteoinductive and osteoconductive properties. Neither bio-derived materials nor synthetic materials can meet the needs of an ideal bone substitute. Preparation of composite materials is a promising way to improve properties of biomaterial. In this study, the porous poly lactic acid (PLA)/demineralized bone matrix (DBM) composite biomaterials prepared by supercritical CO2 technique were implanted to repair rabbit radius segmental bone defect. By comparing with PLA and bone autograft, the X-ray result and histological analysis showed the repair effect of PLA/DBM porous composite materials is significantly better than that of the PLA group and the blank control group, and is similar to autologous bone. The PLA/DBM can promote the healing of bone defects and can be used as a kind of ideal alternative materials to repair bone defects. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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