Greater than the Sum of Its Parts: δ can be Constructed from Item Level Data.
| Autor: | Royall, Donald R., Palmer, Raymond F., Teruyuki Matsuoka, Yuka Kato, Shogo Taniguchi, Mayu Ogawa, Hiroshi Fujimoto, Aiko Okamura, Keisuke Shibata, Kaeko Nakamura, Shutaro Nakaaki, Hiroyuki Koumi, Masaru Mimura, Kenji Fukui, Jin Narumoto, Matsuoka, Teruyuki, Kato, Yuka, Taniguchi, Shogo, Ogawa, Mayu, Fujimoto, Hiroshi |
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| Předmět: |
DIAGNOSIS of dementia
MILD cognitive impairment LIFE skills ACTIVITIES of daily living EXECUTIVE function JAPANESE people HEALTH ALZHEIMER'S disease diagnosis ALZHEIMER'S disease COGNITION disorders diagnosis COGNITION disorders NEUROPSYCHOLOGICAL tests PSYCHOLOGICAL tests RECEIVER operating characteristic curves PSYCHOLOGICAL factors PSYCHOLOGY |
| Zdroj: | Journal of Alzheimer's Disease; 2016, Vol. 49 Issue 2, p571-579, 9p |
| Abstrakt: | "δ", a latent variable constructed from cognitive performance and functional status measures, can accurately diagnose dementia. The minimal assessment needed is unknown. We have constructed a δ homolog, "dTEXAS", from Telephone Executive Assessment Scale (TEXAS) items, and validated it in a convenience sample of Japanese persons (n = 176). dTEXAS scores correlated strongly with both Instrumental Activities of Daily Living (IADL) (r = -0.86, p < 0.001) and Clinical Dementia Rating Scale (CDR) (r = 0.71, p < 0.001). Constructed independently of their diagnoses, dTEXAS scores accurately distinguished dementia versus controls (area under the receiver operating curve [(AUC; ROC) = 0.92], dementia versus mild cognitive impairment (MCI) (AUC = 0.80) and controls versus MCI (AUC = 0.74). These AUCs are higher than those of multiple observed executive measures, as reported recently by Matsuoka et al., 2014. A dTEXAS score of -0.58 best discriminated between dementia versus controls with 90.1% sensitivity and 80.0% specificity. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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