| Autor: |
de Silanes, Isabel López, Fan, Jinshui, Yang, Xiaoling, Zonderman, Alan B, Potapova, Olga, Pizer, Ellen S, Gorospe, Myriam |
| Předmět: |
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| Zdroj: |
Oncogene; 10/16/2003, Vol. 22 Issue 46, p7146-7154, 9p |
| Abstrakt: |
Immunohistochemical analysis of paired tumor and normal tissue specimens revealed that the expression and cytoplasmic abundance of the RNA-binding protein HuR increased with malignancy, particularly in colon carcinomas. Interventions to modulate HuR expression in human RKO colon cancer cells altered gene expression profiles and identified ß-catenin mRNA as a novel HuR target. Subcutaneous injection of HuR-overexpressing RKO cells into nude mice produced significantly larger tumors than those arising from control populations; conversely, RKO cells expressing reduced HuR through small interference RNA- or antisense HuR-based approaches developed significantly more slowly. We propose that HuR-regulated target mRNA expression contributes to colon cancer growth. Our results suggest a pivotal function for HuR in colon carcinogenesis.Oncogene (2003) 22, 7146-7154. doi:10.1038/sj.onc.1206862 [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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