Design, synthesis, and biological evaluation of pyrimidine-2-carboxamide analogs: investigation for novel RAGE inhibitors with reduced hydrophobicity and toxicity.

Autor: Kim, Seok-Ho, Han, Young
Zdroj: Archives of Pharmacal Research; Nov2015, Vol. 38 Issue 11, p1952-1962, 11p
Abstrakt: This paper describes an investigation of novel RAGE inhibitors with improved drug-like properties. To identify the improved drug-like RAGE inhibitor, we designed and synthesized pyrimidine-2-carboxamide analogs based on our previous work. Several potent analogs with improved hydrophilicity were identified by evaluation of RAGE inhibitory activity. In particular, one of the potent (diethylamino)ethoxymethoxy analogs did not exhibit undesired cytotoxicity in contrast with the parent RAGE inhibitors. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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