In Vitro Fertilization, Levels of Pro-Inflammatory Factors and Lipid Peroxidation.
| Autor: | Yildizfer, Ferdag, Donma, Orkide, Yen, Mustafa, Ekmekci, Ozlem, Kul, Zubeyde Asli Karatas, Keser, Zafer, Imal, Ahmet Esat, Cagil, Emin, Mengi, Murat, Ekmekci, Hakan, Sahmay, Sezai, Nalbantoglu, Burcin, Donma, Mustafa Metin |
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| Předmět: |
LIPID metabolism
C-reactive protein CLINICAL trials STATISTICAL correlation ENZYME-linked immunosorbent assay FERTILIZATION in vitro INFLAMMATION LONGITUDINAL method RESEARCH funding SPECTROPHOTOMETRY STATISTICS T-test (Statistics) TUMOR necrosis factors LEPTIN DATA analysis BODY mass index DATA analysis software DESCRIPTIVE statistics MANN Whitney U Test |
| Zdroj: | International Journal of Fertility & Sterility; Oct-Dec2015, Vol. 9 Issue 3, p277-284, 8p, 3 Charts |
| Abstrakt: | Background: Infertility is a problem concerning 10-15% of the individuals in the fertile period. This study investigated effects of proinflammatory factors as well as lipid hydroperoxides (LPO) levels upon in vitro fertilization (IVF) success. Materials and Methods: In this prospective, non-randomized, controlled clinical study, sera obtained from 26 fertile (group-1), 26 infertile women before (group-2) and after (group-3) IVF treatment were analyzed. Leptin, leptin receptor, resistin, tumor necrosis factor-alpha (TNF-α), and C-reactive protein (CRP) were analyzed using enzyme-linked immunosorbent assay (ELISA). LPO was determined spectrophotometrically. Mann- Whitney U test, paired samples t test, Wilcoxon signed-rank test as well as Pearson correlation analysis by SPSS were performed for statistical analysis. Results: TNF-α, resistin and LPO levels increased (P=0.020, P=0.003, P=0.001, respectively) in group-3 compared to group-2. A significant increase in LPO was noted both in group-2 and -3 compared to controls (P=0.000). LPO were higher in non-pregnants than pregnants in group-2. For pregnants, significant correlations were observed between leptin and resistin in group-2 and TNF-α and leptin in group-3. None of these correlations were found for the women, who could not conceive. Conclusion: LPO, leptin-resistin correlation, associations with TNF-α may be helpful during the interpretation of IVF success rates. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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