HMRS results of hippocampus in the patients with obsessive–compulsive disorder before and after cognitive behavioral therapy.
| Autor: | Atmaca, Murad, Yildirim, Hanefi, Yilmaz, Seda, Caglar, Neslihan, Mermi, Osman, Gurok, M. Gurkan, Kekilli, Yasemin, Turkcapar, Hakan |
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| Předmět: |
DIAGNOSIS of obsessive-compulsive disorder
OBSESSIVE-compulsive disorder MENTAL health services ACETYLCHOLINE BIOMARKERS CHI-squared test COGNITIVE therapy HIPPOCAMPUS (Brain) MAGNETIC resonance imaging CLASSIFICATION of mental disorders STATISTICS T-test (Statistics) DATA analysis TREATMENT effectiveness DATA analysis software |
| Zdroj: | International Journal of Psychiatry in Clinical Practice; Oct2015, Vol. 19 Issue 4, p285-289, 5p |
| Abstrakt: | Objective.In the present study, we examined the effects of cognitive behavioral therapy (CBT) on the hippocampal neurochemistry in patients with obsessive–compulsive disorder (OCD).Methods.Twelve patients with OCD and same number of healthy controls were included into the study. Neurochemical variables of the hippocampus were measured before and after the CBT treatment in the patient group.Results.At baseline, the patients with OCD had significantly lower ratio ofN-acetyl-l-aspartate/choline (NAA/CHO) compared with that of healthy control subjects. When comparing pre-treatment results of the patient group with those of post-treatment ones using pairedt-test, we found that NAA/CHO ratio increased from 2.47 ± 0.64 to 3.66 ± 0.88, with a statisical significance.Conclusions.The findings may implicate that CBT increases the level of NAA which is a marker of neuronal integrity. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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