| Autor: |
Aruoma, Okezie I., Moncaster, Juliet A., Walsh, Desmond T., Gentleman, Stephen M., Yun-Fei Liang, Stephen M., Bin Ke, Higa, Teruo, Ling Sun Jen, Teruo |
| Předmět: |
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| Zdroj: |
Free Radical Research; Jan2003, Vol. 37 Issue 1, p91-97, 7p, 2 Color Photographs, 1 Diagram, 1 Graph |
| Abstrakt: |
Injection of the glutamate agonist N-methyl-D-aspartate (NMDA) into the vitreous body of rats resulted in severe degeneration of neurons in the retina, with a loss of 81% of ganglion cells and 43% of non-ganglion cells. The cocktail EM-X is a novel antioxidant drink derived from ferment of unpolished rice, papaya and sea-weeds with effective microorganisms (EM-X). In animals treated with an intra-peritoneal injection of EM-X, the loss of ganglion cells was reduced to 55% and that of non-ganglion cells to 34% when compared to untreated NMDA-injected retinas. Cell degeneration resulting from NMDA excitotoxicity, is thought to be mediated via oxidative stress mechanisms. The neuroprotective effect of the EM-X in this system is therefore likely to be due, at least in part, to its flavonoids, saponins, vitamin E and ascorbic content. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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