Overall Survival Is Impacted by Birthplace and Not Extent of Surgery in Asian Americans with Resectable Gastric Cancer.

Autor: Kirchoff, Daniel, Deutsch, Gary, Fujita, Manabu, Lee, David, Sim, Myung, Lee, Ji, Bilchik, Anton, Kirchoff, Daniel D, Deutsch, Gary B, Lee, David Y, Sim, Myung Shin, Lee, Ji Hey, Bilchik, Anton J
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Zdroj: Journal of Gastrointestinal Surgery; Nov2015, Vol. 19 Issue 11, p1966-1973, 8p
Abstrakt: Survival from gastric cancer in the USA still lags behind Asia. Genetic, environmental, and tumor biology differences, along with extent of surgery have been implicated. Our aim was to evaluate survival outcomes in Asian-American gastric cancer patients undergoing surgical resection by comparing place of birth and clinicopathologic characteristics (including evaluation of 15 lymph nodes).The Surveillance, Epidemiology, and End Results database was queried to identify patients treated surgically for gastric cancer with curative intent in the USA (2000-2010). US-born versus foreign-born Asian-American patients were analyzed for survival. Secondary comparison was made to non-Asian patients. Stage IV and non-surgical patients were excluded. Of 10,089 patients identified, 1467 patients were Asian: 271 were born in the USA, and 1196 were born outside the USA. Median survival was 32 months for non-Asians and 29 months for US-born Asians versus 61 months for Asian immigrants (p < 0.001). On multivariable analysis of overall survival in Asian patients, only US birthplace, older age, and higher stage yielded a significantly poorer outcome. Asian-American patients have a worse prognosis if born in the USA. Anatomic and surgical differences do not explain this disparity; environmental factors may be responsible. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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