| Autor: |
Jonsson, Marie E., Wahlestedt, Jenny Nelander, Åkerblom, Malin, Kirkeby, Agnete, Malmevik, Josephine, Brattaas, Per Ludvik, Jakobsson, Johan, Parmar, Malin |
| Předmět: |
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| Zdroj: |
Development (09501991); Sep2015, Vol. 142 Issue 18, p3166-3177, 12p |
| Abstrakt: |
MicroRNAs (miRNAs) have been implicated in regulating multiple processes during brain development in various species. However, the function of miRNAs in human brain development remains largely unexplored. Here, we provide a comprehensive analysis of miRNA expression of regionalized neural progenitor cells derived from human embryonic stem cells and human foetal brain. We found miR-92b-3p and miR-130b-5p to be specifically associated with neural progenitors and several miRNAs that display both age-specific and region-specific expression patterns. Among these miRNAs, we identified miR-10 to be specifically expressed in the human hindbrain and spinal cord, while being absent from rostral regions. We found that miR-10 regulates a large number of genes enriched for functions including transcription, actin cytoskeleton and ephrin receptor signalling. When overexpressed, miR-10 influences caudalization of human neural progenitor cells. Together, these data confirm a role for miRNAs in establishing different human neural progenitor populations. This dataset also provides a comprehensive resource for future studies investigating the functional role of different miRNAs in human brain development. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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