Procalcitonin as an Early Predictor of Contrast-Induced Acute Kidney Injury in Patients With Acute Coronary Syndromes Who Underwent Percutaneous Coronary Intervention.

Autor:	Kurtul, Alparslan, Murat, Sani Namik, Yarlioglues, Mikail, Duran, Mustafa, Ocek, Adil Hakan, Celik, Ibrahim Etem, Kilic, Alparslan, Koseoglu, Cemal, Oksuz, Fatih, Baris, Veysel Ozgur
Předmět:	ACUTE kidney failure AGE distribution CALCITONIN CHI-squared test CONFIDENCE intervals CREATININE INFLAMMATION MYOCARDIAL revascularization SEX distribution T-test (Statistics) TRANSLUMINAL angioplasty MULTIPLE regression analysis CONTRAST media RECEIVER operating characteristic curves DATA analysis software ACUTE coronary syndrome DESCRIPTIVE statistics ODDS ratio MANN Whitney U Test DISEASE risk factors
Zdroj:	Angiology; Nov2015, Vol. 66 Issue 10, p957-963, 7p
Abstrakt:	Contrast-induced acute kidney injury (CI-AKI) is a major issue after percutaneous coronary intervention (PCI), especially in the setting of acute coronary syndrome (ACS). Contrast-induced acute kidney injury is associated with increased mortality and morbidity. Inflammation plays an important role in the pathophysiology of CI-AKI. Procalcitonin (PCT) is introduced as a new marker of inflammation. We sought to examine whether admission PCT levels predict the development of CI-AKI. Patients (n = 814) were divided into 2 groups, namely, CI-AKI (−) and CI-AKI (+). An increase in serum creatinine of ≥0.5 mg/dL from baseline within 48 to 72 hours of contrast exposure was defined as CI-AKI. Contrast-induced acute kidney injury occurred in 96 (11.8%) patients. The PCT levels were significantly higher in patients with CI-AKI than in those without, 0.11 (0.056-0.495) vs 0.04 (0.02-0.078) µg/L; P < .001. After multivariable analysis, PCT remained a significant independent predictor of CI-AKI (odds ratio 2.544; 95% CI [1.207-5.347]; P = .014) as well as age, women, white blood cell, hemoglobin, glomerular filtration rate, creatine kinase myocarial band, and SYNTAX score. In conclusion, serum PCT levels are independently associated with a risk of CI-AKI in patients with ACS who underwent urgent PCI. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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