Ethosuximide Reduces Mortality and Seizure Severity in Response to Pentylenetetrazole Treatment During Ethanol Withdrawal.
| Autor: | Riegle, Melissa A., Masicampo, Melissa L., Hong Qu Shan, Xu, Victoria, Godwin, Dwayne W. |
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| Předmět: |
COMPLICATIONS of alcoholism
MORTALITY prevention ANALYSIS of variance ANIMAL experimentation ANTICONVULSANTS BIOLOGICAL models CHI-squared test EXPERIMENTAL design GABA antagonists MICE NONPARAMETRIC statistics RESEARCH funding SPASMS STATISTICS ALCOHOL withdrawal syndrome DATA analysis CONVULSANTS DESCRIPTIVE statistics KRUSKAL-Wallis Test PREVENTION THERAPEUTICS |
| Zdroj: | Alcohol & Alcoholism; Sep2015, Vol. 50 Issue 5, p501-508, 8p |
| Abstrakt: | We recently demonstrated that T-type calcium channels are affected by alcohol abuse and withdrawal. Treatment with ethosuximide, an antiepileptic drug that blocks T-type calcium channels, reduces seizure activity induced by intermittent ethanol exposures and withdrawals. Here, we expand on these findings to test whether ethosuximide can reduce the sensitivity to pentylenetetrazole-induced seizures during ethanol withdrawal.~Aims~Objective~We used an intermittent ethanol exposure model to produce withdrawal-induced hyperexcitability in DBA/2J mice.~Methods~Methods~Ethosuximide (250 mg/kg) reduced seizure severity in mice undergoing ethanol withdrawal with concurrent PTZ treatment (20 mg/kg). Importantly, ethosuximide did not produce rebound excitability and protected against ethanol withdrawal-induced mortality produced by concurrent PTZ treatment (40 mg/kg).~Results~Results~These results, in addition to previous preclinical findings, suggest that ethosuximide should be further evaluated as a safe, effective alternative to benzodiazepines for the treatment of alcohol withdrawal.~Conclusion~Conclusions [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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