Decreased SAPK/ JNK signalling affects cytokine release and STAT3 activation in psoriatic fibroblasts.

Autor:	Arasa, Jorge, Terencio, María Carmen, Andrés, Rosa M., Valcuende‐Cavero, Francisca, Montesinos, María Carmen
Předmět:	PROTEIN kinase regulation C-Jun N-terminal kinases regulation CYTOKINES CELLULAR signal transduction GENETIC transcription FIBROBLASTS PSORIASIS
Zdroj:	Experimental Dermatology; Oct2015, Vol. 24 Issue 10, p800-802, 3p
Abstrakt:	The article discusses research on the effect of lowering stress-activated protein kinases and c-Jun N-Terminal kinase on the release of cytokine and activation of signal transducers and activators of transcription (STAT3) in fibroblasts of patients with psoriasis. Topics cited include the differences in the production of interleukin 6 and 8, the signalling pathways between healthy and psoriatic fibroblasts, and the effect of amino acid residue phosphorylation on STAT3 transcriptional activity.
Databáze:	Complementary Index
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