| Autor: |
Mwiru, Ramadhani S, Spiegelman, Donna, Duggan, Christopher, Seage 3rd, George R, Semu, Helen, Chalamilla, Guerino, Kisenge, Rodrick, Fawzi, Wafaie W, Seage, George R 3rd |
| Zdroj: |
Journal of the International Association of Providers of AIDS Care; Mar2015, Vol. 14 Issue 2, p172-179, 8p |
| Abstrakt: |
Background: We assembled a prospective cohort of 3144 children less than 15 years of age initiating antiretroviral therapy (ART) in Dar es Salaam, Tanzania.Methods: The relationships of nutritional status and other baseline characteristics in relation to mortality were examined using Cox proportional hazards model.Results: Compared with children with weight for age (WAZ) > -1, those with WAZ ≤ -2 to < -3 had a nearly double risk of death (relative risk [RR], 1.85; 95% confidence interval [CI], 1.10-3.11), and among those with WAZ ≤ -3, the risk more than tripled (RR, 3.36; 95% CI, 2.12-5.32). Other baseline risk factors for overall mortality included severe anemia (P < .001), severe immune suppression (P = .02), history of tuberculosis (P = .01), opportunistic infections (P < .001), living in the poorest district (P < .001), and advanced World Health Organization stage (P = .003).Conclusions: To sustain the obtained benefit of ART in this setting, interventions to improve nutritional status may be used as an adjunct to ART. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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