| Autor: |
Shiori Nunokawa, Masamitsu Minamisawa, Keiji Nakano, Yoshiyasu Ichikawa, Hiyoshizo Kotsuki |
| Předmět: |
|
| Zdroj: |
Synlett; 2015, Vol. 26 Issue 16, p2301-2305, 5p |
| Abstrakt: |
The enantioselective Michael addition reaction of α-aryl-substituted lactams with electron-deficient olefins was efficiently catalyzed using chiral quaternary ammonium salts derived from cinchona alkaloids. This method was highly useful for the construction of an all-carbon-substituted quaternary carbon stereogenic center at the α-position of lactams in good to high yields and with good enantiomeric excess and could be applied to the short synthesis of (+)-mesembrine. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
