Soshiho-tang water extract inhibits ovalbumin-induced airway inflammation via the regulation of heme oxygenase-1.

Autor:	Woo-Young Jeon, Hyeun-Kyoo Shin, In-Sik Shin, Sang Kyum Kim, Mee-Young Lee
Předmět:	DRUG therapy for asthma THERAPEUTIC use of plant extracts ANALYSIS of variance ANALYTICAL biochemistry ANIMAL experimentation ASTHMA BIOLOGICAL models COLLECTION & preservation of biological specimens ENZYME-linked immunosorbent assay EOSINOPHILS EXPERIMENTAL design IMMUNOHISTOCHEMISTRY INFLAMMATION INFLAMMATORY mediators INTERLEUKINS ASIAN medicine MICE OXIDOREDUCTASES PROBABILITY theory RESEARCH funding STATISTICS PLANT extracts DATA analysis DATA analysis software DESCRIPTIVE statistics
Zdroj:	BMC Complementary & Alternative Medicine; 9/19/2015, Vol. 15 Issue 1, p1-10, 10p, 1 Chart, 5 Graphs
Abstrakt:	Background: Soshiho-tang, known as Xio-hai-Hu-Tang in Chinese and Sho-Saiko-to in Japanese, has been widely used as a therapeutic agent. Its pharmacological effects include anti-inflammatory, antioxidant, antihepatic fibrosis, antitumor and immunomodulating activities. However, little is known regarding its effects on allergic asthma. Therefore, the aim of the present study was to investigate whether the Soshiho-tang water extract (SSTW) has antiasthmatic effects on airway inflammation in an ovalbumin (OVA)-induced mouse model. Methods: BALB/c mice were used as a model of asthma after induction by sensitization and challenge with OVA. We measured change in eosinophils, other inflammatory cells, and T helper 2 (Th2)-type cytokines, such as interleukin (IL)-4, IL-5, IL-13, IL-17, IL-33, and chemokine (eotaxin) in bronchoalveolar lavage fluid (BALF), presence of total and OVA-specific immunoglobulin (Ig)E in plasma, and expression of mucus production and heme oxygenase (HO)-1 protein in lung tissue. Results: Our results show that SSTW had a suppressive effect on eosinophil influx into BALF and decreased the levels of Th2-type cytokines. Moreover, SSTW exhibited a marked decrease in mucus hypersecretion, total and OVA-specific IgE levels, and significantly induced HO-1 protein expression. Conclusions: These results suggest that SSTW may be used as a valuable therapeutic agent for treating various inflammatory diseases including allergic asthma. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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