Polymorphisms in genes of the BAFF/ APRIL system may constitute risk factors of B- CLL - a preliminary study on a Polish population.

Autor: Jasek, M., Wagner, M., Sobczynski, M., Wolowiec, D., Kuliczkowski, K., Woszczyk, D., Kielbinski, M., Kusnierczyk, P., Frydecka, I., Karabon, L.
Předmět:
Zdroj: Tissue Antigens; Oct2015, Vol. 86 Issue 4, p279-284, 6p
Abstrakt: The association of single-nucleotide polymorphisms ( SNPs) of B-cell activating factor ( BAFF)/a proliferation-inducing ligand ( APRIL) system with B-cell chronic lymphocytic leukemia (B- CLL) have been suggested, therefore, we investigated 20 SNPs of BAFF, APRIL, BAFF-R, transmembrane activator and calcium modulator and cyclophilin-ligand interactor ( TACI), B-cell maturation antigen ( BCMA) genes and the risk and outcome of B- CLL in 187 patients and 296 healthy subjects as well as ligand-receptor gene × gene interactions. Although the obtained P-values for all 20 SNPs did not reach statistical significance for this study (α = 0.003), the high value of the global chi-squared statistic (χ2df = 38 = 52.65; P = 0.0586), and obtained values of odds ratio indicate that rs9514828 ( BAFF), rs3803800 ( APRIL) and rs4985726 ( TACI) may be associated with the risk of B- CLL. We observed that the B- CLL patients with the genotype rs9514828CT/ rs11570136AA were diagnosed with the disease 12 years later than the whole group of patients in this study. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje