HLA-A-B-C-DRB1-DQB1 phased haplotypes in 124 Nigerian families indicate extreme HLA diversity and low linkage disequilibrium in Central-West Africa.

Autor:	Testi, M., Battarra, M., Lucarelli, G., Isgro, A., Morrone, A., Akinyanju, O., Wakama, T., Nunes, J. M., Andreani, M., Sanchez‐Mazas, A.
Předmět:	HLA histocompatibility antigens HAPLOTYPES ALLELES LINKAGE disequilibrium NIGERIANS POPULATION genetics
Zdroj:	Tissue Antigens; Oct2015, Vol. 86 Issue 4, p285-292, 8p
Abstrakt:	The simultaneous typing of five- HLA loci at high resolution and the availability of pedigree data allowed us to characterize extended five-locus phased haplotypes in 124 Nigerian families and to compare the observed frequencies with those expected by an expectation-maximization algorithm for unphased data. Despite the occurrence of some frequent alleles at each locus (e.g. B*53:01, which is assumed to protect against Plasmodium falciparum), as many as 82% of the sampled individuals carry two unique five-locus haplotypes and only three extended haplotypes with frequency above 1% exhibit significant linkage disequilibrium. Although preliminary, these results reveal an extreme level of HLA diversity in the Nigerian population, which reflects both its multi-ethnic composition and the very ancient demographic history of African populations. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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