Autor: |
Moghimipour, Eskandar, Ameri, Abdulghani, Handali, Somayeh |
Předmět: |
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Zdroj: |
Molecules; Aug2015, Vol. 20 Issue 8, p14451-14473, 23p, 5 Diagrams, 4 Charts, 4 Graphs |
Abstrakt: |
Bile salts are ionic amphiphilic compounds with a steroid skeleton. Among the most important physiological properties of bile salts are lipid transport by solubilization and transport of some drugs through hydrophobic barriers. Bile salts have been extensively studied to enhance transepithelial permeability for different marker molecules and drugs. They readily agglomerate at concentrations above their critical micelle concentration (CMC). The mechanism of absorption enhancement by bile salts appears to be complex. The aim of the present article was to review bile salt structure and their application as absorption enhancers and the probable mechanism for increasing permeation based on previous studies. [ABSTRACT FROM AUTHOR] |
Databáze: |
Complementary Index |
Externí odkaz: |
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